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Monday, February 27, 2006

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find related articles. powered by google. Forbes Protein Interactions Offer Up Clues to Disease

"Researchers at Johns Hopkins University and the Institute of Bioinformatics in Bangalore, India, analyzed a database of more than 25,000 protein-protein interactions and developed what's believed to be the most detailed human "interactome" -- the interplay of proteins that occurs in cells when people are healthy or when they have disease.

The researchers found that proteins encoded by mutated genes involved in inherited disorders were likely to interact with proteins already known to cause similar disorders. The study also disputes the long-held belief that a specific protein's relative importance is always indicated by the number of other proteins it interacts with in a cell."

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Bioinformatics will be at the core of biology in the 21st century. In fields ranging from structural biology to genomics to biomedical imaging, ready access to data and analytical tools are fundamentally changing the way investigators in the life sciences conduct research and approach problems. Complex, computationally intensive biological problems are now being addressed and promise to significantly advance our understanding of biology and medicine. No biological discipline will be unaffected by these technological breakthroughs.


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