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{bio,medical} informatics

Thursday, October 20, 2005

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find related articles. powered by google. Bio-IT World Venter Raises Stakes for “$1,000 Genome”

"Adding even greater incentive to scientists striving to realize the era of the $1,000 genome sequence, J. Craig Venter announced today that he is seeking to increase the size of his foundation’s prize from $500,000 to as much as $10 million."

"“We’re thinking of a timeline that this has to be done sometime between 2008 and 2010. We’re trying to raise the prize value to reward the scientists that actually come up with these breakthroughs, not by calculation but by actual demonstration.”"

redux [08.05.05]
find related articles. powered by google. Scientific American Recipe for D-I-Y DNA Decoding Revealed

"A thousand dollars can buy a lot of things. Scientists hope to soon add an individual's genetic sequence to that list. Full-genome DNA decoding, estimated to now cost $20 million, could soon be done for about $2.2 million, experts say, and will continue to drop in price as researchers develop new ways to conquer the task. A report published online yesterday by the journal Science suggests one such method: a technique that used off-the-shelf instruments and reagents to successfully sequence the E. coli genome."

find related articles. powered by google. Bio-IT World Harvard Group Develops Low-Cost DNA Sequencing Technique

"Unlike the 454 approach, the method developed by Church and colleagues is a form of DNA resequencing – that is, it requires a reference sequence with which to compare the new sequence, because each fragment of DNA sequenced is so short. Nevertheless, many likely lab applications – from genotyping haplotypes in a disease study, searching for mutations in cancer resistance, or as in the Science paper, identifying microbial strain variants – would fall into this category."

redux [08.01.05]
find related articles. powered by google. Nature Fast sequencing comes to light

"When Jonathan Rothberg's son was born six years ago, the baby was sent to the infant intensive care unit. Rothberg worried all night that something might be wrong with his child, and he found himself wishing he could just read the boy's genome to find out.

At the time that was impossible: it cost tens of millions of dollars and took more than a decade to decipher the first complete human genome, published in 2001 in Nature. But Rothberg's parental panic and frustration inspired him to design a faster, cheaper sequencing technique. Now Rothberg and his co-workers at the 454 Life Sciences Corporation, which he founded, report their success. "

find related articles. powered by google. The New York Times DNA Machine May Advance Genetic Sequencing for Patients
[requires 'free' registration]

""What they have done here is very significant," Dr. Ronaghi said, noting that the company had already sequenced 50 microbial genomes. "This is the first step toward $1,000 human genome sequencing," he said."

"Jonathan Rothberg, board chairman of 454 Life Sciences, said the company was already able to decode DNA 400 units at a time in test machines. It was working toward sequencing a human genome for $100,000, and if costs could be further reduced to $20,000 the sequencing of individual genomes would be medically worthwhile, Dr. Rothberg said."

redux [10.03.02]
find related articles. powered by google. Wired News Get Your Red-Hot Genome CD

"Mapping and reading J. Craig Venter's genome took 15 years, $5 billion and some of the world's most sophisticated computers.

Wouldn't you, too, like your genome decoded?

Venter says he plans to offer the service, with the goal of burning individual human's entire DNA sequences onto shiny compact discs."

find related articles. powered by google. Genomeweb Gene pioneer's next goal

"Tonight's plenary panel discussion at GSAC, "The Future of DNA Sequencing: Advancing Toward the $1,000 Genome," hosted by Craig Venter and Gerald Rubin, quickly turned into a genomics version of the game show "The Price is Right."

"I had to do a little better than the thousand-dollar genome," said VisiGen Biotechnologies CEO Susan Hardin, one of the panelists, about her company's efforts to develop a single-molecule sequencing method using both a modified polymerase and nucleotides. "So we're going for the $995 genome.""

[ rhetoric ]

Bioinformatics will be at the core of biology in the 21st century. In fields ranging from structural biology to genomics to biomedical imaging, ready access to data and analytical tools are fundamentally changing the way investigators in the life sciences conduct research and approach problems. Complex, computationally intensive biological problems are now being addressed and promise to significantly advance our understanding of biology and medicine. No biological discipline will be unaffected by these technological breakthroughs.


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