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Science Daily
Scientists Find Cancer's Genetic Core: 67 Genes Universally Activated In Human Cancer
"Of the approximately 35,000 genes in the human genome, scientists at the University of Michigan’s Comprehensive Cancer Center have found that activity from just 67 is required to change normal human cells into cancer.
These 67 genes constitute what U-M scientists call cancer’s meta-signature – a core set of essential genes, which somehow triggers the transformation from normal cells to cells that are neoplastic, or growing abnormally."
"“We used a statistical analysis method called comparative meta-profiling to examine 40 datasets from other investigators showing specific patterns of genetic activity associated with one of 12 types of cancer,” says Daniel Rhodes, the paper’s first author and a student in the U-M Medical School’s Medical Scientist Training Program and Bioinformatics Graduate Program."
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“Bioinformatics will be at the core of biology in the 21st century. In fields ranging from structural biology to genomics to biomedical imaging, ready access to data and analytical tools are fundamentally changing the way investigators in the life sciences conduct research and approach problems. Complex, computationally intensive biological problems are now being addressed and promise to significantly advance our understanding of biology and medicine. No biological discipline will be unaffected by these technological breakthroughs.”
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