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The Scientist
How Did Natural Selection Shape Human Genes?
[requires 'free' registration]
Many selective forces must have influenced human evolution, but the only one that all population geneticists seem to agree upon is malaria. Time and again, studies have identified certain DNA polymorphisms--most famously, the ß-globin variant underlying red-cell sickling--that helped people resist this mosquito- borne disease. The reproductive success of such individuals spread these polymorphisms throughout regions where malaria is endemic.
Geneticists have been much more reluctant, in contrast, to conclude that other selective forces favored or dis-favored particular polymorphisms. That attitude is changing, however, as technological advances allow the rapid sequencing and analysis of genomes."
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“Bioinformatics will be at the core of biology in the 21st century. In fields ranging from structural biology to genomics to biomedical imaging, ready access to data and analytical tools are fundamentally changing the way investigators in the life sciences conduct research and approach problems. Complex, computationally intensive biological problems are now being addressed and promise to significantly advance our understanding of biology and medicine. No biological discipline will be unaffected by these technological breakthroughs.”
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