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Friday, May 23, 2003

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find related articles. powered by google. Nando Times Don't expect a SARS vaccine soon

"Ultimately bioinformatics will take us through the entire vaccine development process, providing new vaccines at super speed with low development costs. We'll use supercomputers that can imitate the immune system, just as some today can mimic nuclear blasts. Unfortunately, such bioinformatics computers are far beyond anything even on the drawing board.

Meanwhile, it's best to remember that SARS has yet to kill a single American and to vaccinate ourselves against both false fears and hyped expectations."

redux [05.14.03]
find related articles. powered by google. Nature: Science Update SARS' Achilles' heel revealed

"Researchers have made a three-dimensional image of a crucial part of the virus that causes severe acute respiratory syndrome (SARS). The model suggests that a drug being tested as a cold remedy is a good starting point in treating the killer disease."

""It's the Achilles' heel of the virus," says biochemist Rolf Hilgenfeld of the University of Luebeck in Germany, who led the team behind the model. "We're convinced that hitting this target will be enough to stop infection.""

redux [05.01.03]
find related articles. powered by google. Wired News Few Clues from SARS Gene Sequence

"Scientists who have sequenced all the genetic material of the SARS virus said on Thursday they are still stumped by the previously unknown microbe.

They said it had yielded practically no clues about where it came from or why it infects and sometimes kills people. And because there is nothing similar to compare it with, it will take some time to tease out its secrets."

redux [04.15.03]
find related articles. powered by google. Genomeweb Canadian Team Leader: SARS Coronavirus Genome Has 11 Novel ORFs

"The sequenced coronavirus believed to cause Severe Acute Respiratory Syndrome has eleven open reading frames, and these predicted coding regions lack homology to sequence in existing gene databases, Steven Jones, director of bioinformatics at the British Columbia Cancer Center, said today.

"People were thinking that [the SARS virus] was some kind of hybrid virus between a fairly well studied human virus, recombined with a non-human virus," he said. "A lot of those Asian flus have been associated with avian viruses." But the ORFs that Jones' group is finding all have consistent phylogeny. "They all look like they have been in the same organism for a long period of time," he said. And they are "only modestly similar to [ORFs in] other coronaviruses.""

find related articles. powered by google. Canada.Com Code Breakers

"After accomplishing what no other group of scientists has done, they celebrated with a round of doughnuts and a sigh of relief.

It was 4 a.m. Sunday, and the scientists at the Michael Smith Genome Sciences Centre in Vancouver had published the draft sequence of what is suspected to be the SARS virus."

[ rhetoric ]

Bioinformatics will be at the core of biology in the 21st century. In fields ranging from structural biology to genomics to biomedical imaging, ready access to data and analytical tools are fundamentally changing the way investigators in the life sciences conduct research and approach problems. Complex, computationally intensive biological problems are now being addressed and promise to significantly advance our understanding of biology and medicine. No biological discipline will be unaffected by these technological breakthroughs.


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