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{bio,medical} informatics

Thursday, April 24, 2003

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find related articles. powered by google. Wired News Biotech Inventor Wins Big Bucks

"Leroy Hood has the kind demeanor of a kindergarten teacher. But his vocabulary belies his real identity: the most important inventor in modern biology.

Not that he's unconcerned about school kids. Hood has worked to make the science curriculum in Seattle-area K through 12 schools one of the best in the country. But the focus of his career, and the reason MIT has awarded him the $500,000 Lemelson-MIT Prize, is the invention of technologies that are the backbone of the life sciences today."

redux [04.26.03]
find related articles. powered by google. The Seattle Times Creating a 'hothouse' for bioscience research

"When Dr. Leroy Hood sits down to talk about his latest ambition, he takes all of 10 seconds to warm up.

"I think we'll lead the way toward revolutionizing new ways of understanding biology," he said."

"But Hood's enthusiasm these days has been limited by finances. More than two years after an unceremonious exit from the University of Washington, he has been scrounging for money. And his newest vision -- using high-speed computers to turn the DNA jumble into something useful for predicting and preventing disease -- requires lots of money."

redux [01.19.02]
find related articles. powered by google. O'Reilly Network An Interview with Dr. Leroy Hood

"The integration of bioinformatics with these systems approaches is an integral, essential feature. One of the things that we stress is that in the future it's going to be increasingly important for people in bioinformatics to be intimately associated with data producers, because no matter how smart you are you can't model biological complexity--it's just too complex. The only way we're going to understand it is through the integration of these global experimental observations, together with powerful computational tools for analysis, and ultimately, for modeling.

A mistake that a lot of people in bioinformatics have tended to make is thinking that you can set up a bioinformatics center and it can work in isolation from the biology, and it can study all these great databases and learn lots and lots about biology. In vitro biology and in silico biology are all popular terms, but it isn't true, and it isn't going to be true in the future."

redux [04.18.01]
find related articles. powered by google. The New York Times Approaching Biology From a Different Angle
[requires 'free' registration]

"Systems biology is a loosely defined term, but the main idea is that biology is an information science, with genes a sort of digital code. Moreover, while much of molecular biology has involved studying a single gene or protein in depth, systems biology looks at the bigger picture, how all the genes and proteins interact. Ultimately the goal is to develop computer models that can predict the behavior of cells or organisms, much as Boeing can simulate how a plane will fly before it is built.

But such a task requires biologists to team up with computer scientists, engineers, physicists and mathematicians. The structure of universities makes that difficult, Dr. Hood said."

[ rhetoric ]

Bioinformatics will be at the core of biology in the 21st century. In fields ranging from structural biology to genomics to biomedical imaging, ready access to data and analytical tools are fundamentally changing the way investigators in the life sciences conduct research and approach problems. Complex, computationally intensive biological problems are now being addressed and promise to significantly advance our understanding of biology and medicine. No biological discipline will be unaffected by these technological breakthroughs.


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