{bio,medical} informatics
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The Economist
deCODED?
"AMID the brouhaha surrounding the Human Genome Project and its commercial rivals, the fact that there is more than one way to map a genome has got rather lost."
"Linkage mapping has been somewhat neglected in recent years. The best available map was created in 1998 (a lifetime ago, in modern genetic science) by the Marshfield Medical Research Foundation, in Wisconsin, based on data collected in France. But a new one has just been published by deCODE, an Icelandic firm, in Nature Genetics. Besides being at higher resolution than the Marshfield map, it reveals some intriguing facts about human reproduction. It also reveals the whereabouts of what the company hopes might prove to be very lucrative genes."
[requires 'free' registration]
"In the year 874, Viking crews from western Norway started to drop in on Ireland, capture an allotment of young Celtic women and sail off northwest to a remote island beyond the reach of retribution.
Eleven centuries later, a direct descendant of those Icelandic pirates and their slave wives, Dr. Kari Stefansson, says he is starting to extract a tremendous prize, made possible by Iceland's tiny, isolated population and its obsessive interest in genealogy: a catalog of the deviant genes that cause the most common human diseases."
redux [06.10.02]
"Kari Stefansson and his colleagues at deCODE genetics created a new genome map by combining their extensive database of genetic data from 146 Icelandic families with the DNA sequence of the Human Genome Project (HGP). In the process, they were able to increase the accuracy of the genetic map five-fold and correct 104 mistakes in the HGP draft."
"The company plans to make the new map freely available to researchers."
[ rhetoric ]
“Bioinformatics will be at the core of biology in the 21st century. In fields ranging from structural biology to genomics to biomedical imaging, ready access to data and analytical tools are fundamentally changing the way investigators in the life sciences conduct research and approach problems. Complex, computationally intensive biological problems are now being addressed and promise to significantly advance our understanding of biology and medicine. No biological discipline will be unaffected by these technological breakthroughs.”
BIOINFORMATICS IN THE 21st CENTURY[ search ]
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gene expression
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free association
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informatics review
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