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The Scientist
The Human Genome — One Year Later
[requires 'free' registration]
"Francis Collins, director, National Human Genome Research Institute, asserts, "From a careful reading of the Celera February Science paper it does not appear that the whole genome shotgun approach was able to assemble the human sequence on its own." The fact that Celera used the publicly available GenBank sequence to help compile its draft proves the point, Collins says.
There was a reason for that, Venter says. "One of the assumptions we'd made was that more data was going to be better than less data. It turns out in retrospect that was clearly a naïve assumption." A reassembly of the human genome sans public data has yielded a sequence almost two orders of magnitude better, and published results on this finding are forthcoming, he says. "None of this changes the analysis, but what this would have done is change the controversy that it wouldn't have worked without the public data.""
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“Bioinformatics will be at the core of biology in the 21st century. In fields ranging from structural biology to genomics to biomedical imaging, ready access to data and analytical tools are fundamentally changing the way investigators in the life sciences conduct research and approach problems. Complex, computationally intensive biological problems are now being addressed and promise to significantly advance our understanding of biology and medicine. No biological discipline will be unaffected by these technological breakthroughs.”
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