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{bio,medical} informatics

Friday, January 18, 2002

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find related articles. powered by google. BioMedCentral Computer turns detective in the hunt for novel pathogens

"The potential for rapid discovery of new, disease-causing microbes, is on the horizon with successful results from a study with a new computerized technique - computational subtraction - that uses DNA matching to isolate and identify microbial gene sequences.

Computational subtraction is an in silico approach that takes advantage of the nearly completed DNA sequence of the human genome, made available through the Human Genome Project . By subtracting out the full complement of human DNA sequences from DNA libraries derived from human tissues, researchers at the Dana-Farber Cancer Institute and Harvard Medical School found they were left with a small number of DNA sequences, presumably of nonhuman origin. They could then search these sequences for evidence of microbial genes, and establish possible links between previously unknown organisms and human disease."

[ rhetoric ]

Bioinformatics will be at the core of biology in the 21st century. In fields ranging from structural biology to genomics to biomedical imaging, ready access to data and analytical tools are fundamentally changing the way investigators in the life sciences conduct research and approach problems. Complex, computationally intensive biological problems are now being addressed and promise to significantly advance our understanding of biology and medicine. No biological discipline will be unaffected by these technological breakthroughs.


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