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{bio,medical} informatics

Tuesday, December 04, 2001

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"BLAST is arguably the most valuable bioinformatics tool developed to date, but it is not the only program that can perform sequence similarity searches, nor is it the best choice for all applications. As other choices become more prevalent in the community, it is vital that we develop a shared understanding of the fundamental biological questions addressed as well as a methodology for transforming, comparing, and replicating results produced with different implementations and algorithms.

In this article, I discuss some example scenarios in which life scientists perform sequence-based homology searches, and the pitfalls they should be aware of when using any heuristic algorithm."

[ rhetoric ]

Bioinformatics will be at the core of biology in the 21st century. In fields ranging from structural biology to genomics to biomedical imaging, ready access to data and analytical tools are fundamentally changing the way investigators in the life sciences conduct research and approach problems. Complex, computationally intensive biological problems are now being addressed and promise to significantly advance our understanding of biology and medicine. No biological discipline will be unaffected by these technological breakthroughs.


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