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{bio,medical} informatics

Tuesday, December 11, 2001

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find related articles. powered by google. Bio.OReilly.Com An Interview with Lincoln Stein

"Today, Lincoln is a researcher at the Cold Spring Harbor Laboratory in Cold Spring Harbor, New York, as well as a prolific programmer and author. In addition to the significant contributions he has made to Perl and the Web, he writes software for biological databases, data analysis and visualization, and sharing results. He writes for Web Techniques and The Perl Journal, and he has written several books on related subjects."

"We spoke to Lincoln about his current projects, his opinion on patent issues in biology, and why Perl has become the programming language of choice in bioinformatics."

redux [04.05.00]
find related articles. powered by google. Wired News Researcher Borrows from Napster

"A researcher working on the Human Genome Project is using Napster technology, and he's not looking for T3 connections to download Moby.

Dr. Lincoln Stein, an associate professor of bioinformatics at the Cold Spring Harbor Lab in New York, is investigating ways to use Napster-type technology to allow scientists to share their discoveries of the genome.

"I was very interested when I saw Napster," Stein said. "It has a similar architecture (to what we use now), but it allows for 'peer-to-peer' data exchange and it dawned on me that it would be marvelous for our annotation system."

find related articles. powered by google. Stein Laboratory Distributed Sequence Annotation System (DAS)

"The pace of human genomic sequencing has outstripped the ability of sequencing centers to annotate and understand the sequence prior to submitting it to the archival databases. Multiple third-party groups have stepped into the breach and are currently annotating the human sequence with a combination of computational and experimental methods. Their analytic tools, data models, and visualization methods are diverse, and it is self-evident that this diversity enhances, rather than diminishes, the value of their work."

"The solution that we advocate allows sequence annotation to be decentralized among multiple third-party annotators and integrated on an as-needed basis by client-side software.

[ rhetoric ]

Bioinformatics will be at the core of biology in the 21st century. In fields ranging from structural biology to genomics to biomedical imaging, ready access to data and analytical tools are fundamentally changing the way investigators in the life sciences conduct research and approach problems. Complex, computationally intensive biological problems are now being addressed and promise to significantly advance our understanding of biology and medicine. No biological discipline will be unaffected by these technological breakthroughs.


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