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{bio,medical} informatics

Wednesday, July 25, 2001

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The Washington Post Celera Aims to Spot Genetic Differences

"Celera Genomics Corp. is launching an ambitious effort to identify the genetic variations responsible for human disease, a move the Rockville firm hopes will bolster its plans to develop new drugs and diagnostic tests."

The company that mapped the human genome plans to turn its scientific expertise toward finding the tiny genetic differences, known as SNPs, for single nucleotide polymorphisms, that make individuals unique. The project will focus on SNPs linked to disease and varying patient responses to medicine."

"The initiative is part of a broader strategy by Celera's parent company, Applera Corp. of Norwalk, Conn., to cash in on the vast amounts of genetic information generated by Celera's mapping of the human genome."

The Standard Celera Enters a New Genome Race
"Celera, which has one of the nation's largest civilian computer complex, could conceivably surge ahead of companies such as Orchid in the SNP race. But scientists say that when it comes to applying SNPs to drug development, the goals are much broader and vaguer than they were during the race to sequence the human genome.

"Unlike the moon shot that the sequencing of the human genome represented, where there's such a well defined goal, the next age of value development of genetic diversity is going to be characterized by diversity itself," says Dale Pfost, the CEO of Orchid. "There's going to be a range of strategies.""
GenomeWeb Celera Diagnostics Begins to Find its Place Within Applera
"Celera Genomics may be responsible for generating the genomic data that will fuel Applera's new $75 million initiative to reach commercial success, but its sister company Applied Biosystems will initially benefit the most from Celera's genome and SNP mapping activities, executives for the companies said Tuesday."

""We figure that the ability of people to get useful information from studying a host of biological problems in a large number of individuals results in a much bigger experimental load that needs to be fed by a reagent stream, as well as instrument systems," said Hunkapiller. "We would see this as a really big opportunity for us.""

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“Bioinformatics will be at the core of biology in the 21st century. In fields ranging from structural biology to genomics to biomedical imaging, ready access to data and analytical tools are fundamentally changing the way investigators in the life sciences conduct research and approach problems. Complex, computationally intensive biological problems are now being addressed and promise to significantly advance our understanding of biology and medicine. No biological discipline will be unaffected by these technological breakthroughs.”

BIOINFORMATICS IN THE 21st CENTURY

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