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{bio,medical} informatics

Monday, July 30, 2001

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find related articles. powered by google. HHMI Bulletin Rosetta Tackles the Extreme Origami of Protein Folding

"Protein folding has been called one of the great unsolved mysteries of molecular biology, a process too complex and elusive to predict with accuracy. Recently, however, a team led by HHMI investigator David Baker at the University of Washington School of Medicine has begun making predictions that one admiring expert compares to a string of home runs."

"Baker has developed a computational technique, called Rosetta, that predicts the ways in which proteins, which start out as the string-like amino acid sequences that emerge from the protein-synthesis machinery, undergo a folding process that might be dubbed "extreme origami.""

redux [01.20.01]
find related articles. powered by google. Nature: Science Update Protein predictors need start to finish

"Figuring out the shape of the proteins encoded by the thousands of genes in every cell may have just got a little easier. Researchers in Switzerland have made a discovery which they say "pushes the simulation of protein folding processes within reach"1. It is all about knowing where to start."

"An unfolded or 'denatured' protein is not compacted into a well-organized shape. It is more like a loosely tangled ball floating in water. Attempts to model protein folding by computer often assumed that it doesn't matter much what denatured state you start with, since they are all more or less equally messy.

Not so, says van Gunsteren's team..."

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Bioinformatics will be at the core of biology in the 21st century. In fields ranging from structural biology to genomics to biomedical imaging, ready access to data and analytical tools are fundamentally changing the way investigators in the life sciences conduct research and approach problems. Complex, computationally intensive biological problems are now being addressed and promise to significantly advance our understanding of biology and medicine. No biological discipline will be unaffected by these technological breakthroughs.


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