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Wired News
A Search for the Healthy Genes"Like many revolutionary ideas, his point is simple. Researchers trying to develop drugs focus on figuring out why people get diseases.
Why not instead try to figure out why people stay healthy?
"It's wrong to first look for mutated bad genes," Olsen said. "Why not look for mutated genes that make people healthier? The concept that understanding a basic biological defects is most important (for developing drugs) is not actually logical."
Most of the activity in genetic research is focused on finding disease-associated genes. Almost every day it seems one researcher or another announces a new gene discovery. But it's no simple task to fix broken genes, and this approach is getting researchers nowhere fast, Olsen said.
He called it the "gene today, gone tomorrow" syndrome. Researchers find a disease gene, but the discovery offers no way to intervene in the disease pathway."
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“Bioinformatics will be at the core of biology in the 21st century. In fields ranging from structural biology to genomics to biomedical imaging, ready access to data and analytical tools are fundamentally changing the way investigators in the life sciences conduct research and approach problems. Complex, computationally intensive biological problems are now being addressed and promise to significantly advance our understanding of biology and medicine. No biological discipline will be unaffected by these technological breakthroughs.”
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