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Friday, April 21, 2000

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GeneLetter Unusual polymorphisms in HIV-1 associated with slow or no disease progression
"Patients with nonprogressive HIV-1 infection exhibit difficult-to-revert polymorphisms in HIV-1 sequences, according to a report in the May issue of the Journal of Virology."

"Dr. Desrosiers and colleagues conclude, "Although we have not directly demonstrated that these deletions have contributed to [the patients'] rate of disease progression, they appear to be associated with the unusual clinical status of these individuals in an apparently nonrandom fashion."

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Bioinformatics will be at the core of biology in the 21st century. In fields ranging from structural biology to genomics to biomedical imaging, ready access to data and analytical tools are fundamentally changing the way investigators in the life sciences conduct research and approach problems. Complex, computationally intensive biological problems are now being addressed and promise to significantly advance our understanding of biology and medicine. No biological discipline will be unaffected by these technological breakthroughs.


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