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Tuesday, March 21, 2000

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Yahoo! News Celera to Do Breast Cancer Gene Study
"Celera Genomics, one of the companies racing to use information from gene-mapping to make profits, said on Monday it had hooked up with a cancer center to find genes associated with breast cancer.

Celera, based in Rockville, said it signed an agreement with the Duarte, California-based City of Hope Cancer Center to get clinical information from breast cancer patients and sequence their DNA.

``We hope that this collaboration will enable clinical investigators to develop better ways to prevent, diagnose, and treat breast cancer,'' Dr. Sam Broder, chief medical officer of Celera and a former director of the National Cancer Institute, said in a statement."

"They will look for single nucleotide polymorphisms (SNPs), which are single-letter alterations in the nucleotides, the four different molecules known as A, T, G and C that combine in long strings to make up the genetic code."
redux [02.18.00]
Science SNP Mappers Confront Reality and Find It Daunting
[summary - can be viewed for free once registered]
"The genetic markers called SNPs have been widely touted as the key to personalized medicine, with drugs tailored to an individual's genotype and simple tests to determine one's risk of specific diseases. But a closed meeting held last week, sponsored by the SNP Consortium and the U.S. National Human Genome Research Institute, concluded that those promises may be harder to achieve than expected, and that more SNPs may be required to track down a particular disease gene than previously estimated.”

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Bioinformatics will be at the core of biology in the 21st century. In fields ranging from structural biology to genomics to biomedical imaging, ready access to data and analytical tools are fundamentally changing the way investigators in the life sciences conduct research and approach problems. Complex, computationally intensive biological problems are now being addressed and promise to significantly advance our understanding of biology and medicine. No biological discipline will be unaffected by these technological breakthroughs.


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