"Lee Hood, president of the Institute for Systems Biology, has called the premise of the Cancer Genome Project "naïve," suggesting that signal-to-noise issues its researchers are likely to encounter will be "absolutely enormous.""
Hood said the premise of the project -- as he put it, to sequence "to a certain extent" 250 genomes from four or five cancers with the aim of correlating the genetic differences of a particular cancer -- "is a naïve approach because the signal-to-noise issues ... from sequencing cancer genomes on six or seven dimensions are absolutely enormous.""
“Bioinformatics will be at the core of biology in the 21st century. In fields ranging from structural biology to genomics to biomedical imaging, ready access to data and analytical tools are fundamentally changing the way investigators in the life sciences conduct research and approach problems. Complex, computationally intensive biological problems are now being addressed and promise to significantly advance our understanding of biology and medicine. No biological discipline will be unaffected by these technological breakthroughs.”BIOINFORMATICS IN THE 21st CENTURY
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