"The database addresses an important problem: The hundreds of complete genome sequences in the three public DNA databases - EMBL-Bank, GenBank and DDBJ - typically remain static after they have been deposited, even though they are constantly being annotated, revised, and updated by the research community.
Updated every two weeks, Genome Reviews includes some 2.5 million cross-references to many other resources such as encoded proteins in UniProt, the GO Annotation database, or information about related proteins in InterPro. "Perhaps most importantly," says developer Paul Kersey, "we've standardized annotations that are used inconsistently in the original submissions, so it's now much easier to compare the data across several genomes."
“Bioinformatics will be at the core of biology in the 21st century. In fields ranging from structural biology to genomics to biomedical imaging, ready access to data and analytical tools are fundamentally changing the way investigators in the life sciences conduct research and approach problems. Complex, computationally intensive biological problems are now being addressed and promise to significantly advance our understanding of biology and medicine. No biological discipline will be unaffected by these technological breakthroughs.”BIOINFORMATICS IN THE 21st CENTURY
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