{bio,medical} informatics
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The Scientist
Chip Critics Countered
[requires 'free' registration]
"Since their rise to fame in the mid 1990s, microarrays have been both lauded and criticized. Enthusiasm about this technology, which many researchers say has forever fundamentally changed biology, is tempered by the recognition that the microarray, like any tool or technology, has its limits. Results are often hard to reproduce and interpret, and the data-driven approach encouraged by the technology can make microarray studies little more than what critics call "fishing expeditions.""
"Microarrays also have been criticized for being, at best, "semi-quantitative," meaning specific gene expression measures may not consistently be confirmed on separate occasions or by other methods. Some debate the issue's significance. "Your ability to look at so many pathways at one time really points to the virtue," says Sistare. "I may not get the exact same numbers, but I'm seeing the same pathways activated. The biology, the interpretation I'm getting is the same.""
[ rhetoric ]
“Bioinformatics will be at the core of biology in the 21st century. In fields ranging from structural biology to genomics to biomedical imaging, ready access to data and analytical tools are fundamentally changing the way investigators in the life sciences conduct research and approach problems. Complex, computationally intensive biological problems are now being addressed and promise to significantly advance our understanding of biology and medicine. No biological discipline will be unaffected by these technological breakthroughs.”
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