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{bio,medical} informatics

Tuesday, April 15, 2003

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find related articles. powered by google. Genomeweb Canadian Team Leader: SARS Coronavirus Genome Has 11 Novel ORFs

"The sequenced coronavirus believed to cause Severe Acute Respiratory Syndrome has eleven open reading frames, and these predicted coding regions lack homology to sequence in existing gene databases, Steven Jones, director of bioinformatics at the British Columbia Cancer Center, said today.

"People were thinking that [the SARS virus] was some kind of hybrid virus between a fairly well studied human virus, recombined with a non-human virus," he said. "A lot of those Asian flus have been associated with avian viruses." But the ORFs that Jones' group is finding all have consistent phylogeny. "They all look like they have been in the same organism for a long period of time," he said. And they are "only modestly similar to [ORFs in] other coronaviruses.""

find related articles. powered by google. Canada.Com Code Breakers

"After accomplishing what no other group of scientists has done, they celebrated with a round of doughnuts and a sigh of relief.

It was 4 a.m. Sunday, and the scientists at the Michael Smith Genome Sciences Centre in Vancouver had published the draft sequence of what is suspected to be the SARS virus."

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Bioinformatics will be at the core of biology in the 21st century. In fields ranging from structural biology to genomics to biomedical imaging, ready access to data and analytical tools are fundamentally changing the way investigators in the life sciences conduct research and approach problems. Complex, computationally intensive biological problems are now being addressed and promise to significantly advance our understanding of biology and medicine. No biological discipline will be unaffected by these technological breakthroughs.


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