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BBC
Anthrax gene code unravelled
""Scientists have the technology now which allows them to see exactly which genes are switched on or off. Having this information may reveal chinks in the armour of anthrax."
Another bacterial specialist, Professor Chris Wilmott, from the University of Leicester, warned that the genome data would not bear fruit for patients for some time - and doctors would have to be careful not to over-use effective drugs in the meantime."
"Scientists say they've found potential new targets for drugs and vaccines against the anthrax germ by deciphering and analyzing the bacterium's complete genetic makeup."
"For vaccines, the leads come from the study's indications that certain proteins are displayed on the bacterium's surface, he said."
"The research confirmed that the Bacillus anthracis isolated from a terror attack in Florida was different from closely related anthrax strains, the scientists reported. Researchers, using a comparison of the whole-genome sequence of the Florida sample with other strains, also confirmed that the anthrax discovered in Florida was derived from the Ames strain.
The scientists found 60 new genomic markers that include four "high quality" SNPs that were found to divide a collection of anthrax isolates into distinct families, according to the paper's authors."
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“Bioinformatics will be at the core of biology in the 21st century. In fields ranging from structural biology to genomics to biomedical imaging, ready access to data and analytical tools are fundamentally changing the way investigators in the life sciences conduct research and approach problems. Complex, computationally intensive biological problems are now being addressed and promise to significantly advance our understanding of biology and medicine. No biological discipline will be unaffected by these technological breakthroughs.”
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