Wednesday, December 04, 2002

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Genomeweb Of Mice and Men: Consortium Publishes Mouse Genome, Comparative Human Analysis

"The mouse has roughly 27,000 to 30,500 genes, 99 percent of which have a sequence match in the human genome. Syntenic comparisons showed that a subset of 13,000 orthologous gene pairs had a mean sequence identity of about 78.5 percent."

"Other findings, all published in the current issue of Nature, will come as no surprise to anyone who has tried to keep the little beasts out of the pantry: Mice seem to have a wealth of genes that govern sexual behavior and the sense of smell."

Nature: Science Update Plans of mice and men

"When you compare the mouse and human genomes, two things leap out, says Bob Waterston, a genomics researcher at Washington University in St Louis. "The first thing is how similar they are. The second is how different.""

"Mice and humans each have about 30,000 genes, but only a few hundred are unique to one species or the other. "The types of genes in each organism are basically the same," says Waterston. Even the vast stretches of DNA between genes show striking similarities."

redux [08.04.02]
Wired News Scientists Map Mouse Genome

"An international team has completed the most comprehensive map ever of the genetic code of the mouse, an accomplishment that will make the laboratory animal more useful to scientists studying human health and disease.

The map covers an estimated 98 percent of the order of the nearly 3 billion letters that make up the mouse code, or genome. Two efforts have nearly completed the deciphering of those letters, and the map will serve as an atlas of the genome and allow scientists to zero in on regions of interest. It will also permit scientists to fill in gaps that remain in the deciphering efforts, which remain in draft form."

Independent News Uncovering the shared links of mice and men

"Centuries ago, maps were views of the world around us. Today, newly drawn maps are not of the exterior world, but of the world encapsulated by our genes, and the genes of other organisms that share our heritage going back millions, or even billions, of years.

That is why researchers will be poring over the publication this morning of a complete map of the genome of the mouse, the first mammal aside from man to have had all of its DNA sequenced."

NCBI Mouse Genome Resources

"Genomic resources for the mouse are increasing at an astounding pace. The ability to manipulate the mouse genome coupled with the availability of genome sequence make the mouse a unique research tool. This page is a gateway to mouse resources in and beyond NCBI."

redux [10.06.00]
The New York Times $58 Million Race Is On to Decode Mouse Genome by February
[requires 'free' registration]

"With the work on the human genome essentially complete, the National Institutes of Health and others said today that they would spend $58 million to decode the genome of the mouse by February.

While this may seem a large sum to drop on a mouse, experts regard the mouse genome as an invaluable guide for interpreting the human genome sequence that is now in hand.

The initiative represents a continuation of the tussle between the public consortium that decoded the human genome and its competitor, the Celera Corporation."