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Thursday, May 17, 2001

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find related articles. powered by google. GenomeWeb Proteomics Expert Says Technology Lags Corporate Promises
"Many proteomics companies are promising more than they can deliver because they don’t yet have the technology to isolate and characterize low abundance proteins, Ian Humphery-Smith, a protein chemist at the University of Utrecht and the organizer of the Human Proteome Organization, said Thursday.

While companies, such as Large Scale Biology and Myriad, have touted the ability of their technology to pick out most of the proteins in certain cells, they haven’t identified more than five percent of the proteins in the human body, Humphery-Smith said."

"Humphery-Smith said protein microarray technology is the most likely to discover therapeutically important proteins because it will allow researchers to precisely study how the proteins in cells change with disease."
redux [04.28.01]
find related articles. powered by google. GenomeWeb Experts Question Value of Myriad's Proteome Mapping Strategy
"Myriad Genetics made a splash earlier this month when it announced a collaboration with Hitachi and Oracle to "map the human proteome" by 2004.

The scope of this ambitious task could vary widely, depending on how the companies want to define "map" and how thorough they want to be. But regardless of how Myriad and its collaborators define the outer limits of the project, proteomics experts are questioning how much scientific value there is Myriad's basic approach.

These scientists say Myriad's two pronged attack on the proteome, an automated yeast two-hybrid strategy combined with MALDI-TOF mass mass spectroscopy analysis of protein complexes, won' t provide Myriad and its partners with a thorough understanding of how proteins play a role in disease."

redux [03.31.01]
find related articles. powered by google. The Scientist Is a Human Proteome Project Next?
[requires 'free' registration]
"A commonly expressed opinion is that a single Human Proteome Project can never match HGP's success. Eric S. Lander , director of the Whitehead Center for Genome Research in Cambridge, Mass., notes that biologists simply don't know how to characterize the proteome "from end to end, nailing every protein. The tools are not ready. And it's not clear that [such a project] makes sense." He contrasts proteomics to HGP where "there is a certain fixed number of base pairs--about three billion--and we were going to get them all. And so it had a beginning and an end to it."

redux [01.31.01]
find related articles. powered by google. GenomeWeb Proteomics Effort Shouldn't Mimic Genome Project, Experts Say
"Can sequencing do for the proteome what it did for the genome?

On Wednesday, a number of world-renowned researchers in the field of proteomics issued a resounding " no."

Instead of devoting their efforts to decoding the human proteome, proteomics researchers should focus on developing a larger picture of protein structure, function, and pathways within cells and organisms, panelists said at a New York Academy of Sciences briefing entitled "The Promise of Proteomics."

"When a company has phenomenal success with strategy A, you want to do strategy A on the next subject," said John Richards, a professor of organic and biochemistry at California Institute of Technology, referring to current corporate attempts to map the proteome.

"This doesn't work," he said."


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Bioinformatics will be at the core of biology in the 21st century. In fields ranging from structural biology to genomics to biomedical imaging, ready access to data and analytical tools are fundamentally changing the way investigators in the life sciences conduct research and approach problems. Complex, computationally intensive biological problems are now being addressed and promise to significantly advance our understanding of biology and medicine. No biological discipline will be unaffected by these technological breakthroughs.

BIOINFORMATICS IN THE 21st CENTURY

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