{bio,medical} informatics
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EurekAlert
Science's Top 10: genome sequencing named top scientific advance of 2000 "The editors at the international journal, Science, have compiled their list of the Top 10 scientific developments for the year 2000, placing genome sequencing first on the list.
Science's Top 10 research advances, chosen for their profound implications for society and the advancement of science, appear in the journal's 22 December 2000 issue."
[summary - can be viewed for free once registered]
"2000 was a banner year for scientists deciphering the "book of life"; this year saw the completion of the genome sequences of complex organisms ranging from the fruit fly to the human. Science marks the production of this torrent of genome data as the Breakthrough of 2000; it might well be the breakthrough of the decade, perhaps even the century, for all its potential to alter our view of the world we live in.”
redux [10.17.00]
[requires 'free' registration]
"What can people expect from biotechnology and genomics? Ten luminaries from the biomedical arena, law, and journalism grappled with issues related to that question at the City University of New York's Graduate Center on Sept. 20. In attendance was an audience of 350 whose research, medical, and counseling careers could hinge on how such issues are resolved. Syracuse University's Gene Media Forum (www.genemedia.org) sponsored the event.
The recurring theme was biological predictability. Eric Lander, director of the Whitehead Institute Center for Genome Research, in Cambridge, Mass., noted that in the past century, biologists "worked out a disease by being clever enough to figure out what was wrong." The systematic approach of genomics, he continued, would render research largely predictable.
Panelists stressed, nevertheless, that genomics would not yield answers easily. Harold Varmus, president of Memorial Sloan-Kettering Cancer Center in New York, said that biologists were used to studying one gene at a time. Now, he added, "you've got all the parts of the clock dumped on the table, and you can look at them. But, you know, it's a lot harder to put back together, too."
A consensus emerged that much of the public--including many journalists, behavioral scientists, and physicians--either were unaware of this newfound complexity or twisted it into misguided support for genetic determinism. "
redux [06.26.00]
""How it's going to help me develop drugs or do anything, I really don't have a clue," said Craig Rosen, executive vice president for research and development at Human Genome Sciences."
""It's like being given the best book in the world, but it's in Russian, and it's incredibly boring to read," said Ewan Birney, a team leader at the European Bioinformatics Research Institute, part of the Sanger Centre, one of the major labs working on the Human Genome Project."
[ rhetoric ]
“Bioinformatics will be at the core of biology in the 21st century. In fields ranging from structural biology to genomics to biomedical imaging, ready access to data and analytical tools are fundamentally changing the way investigators in the life sciences conduct research and approach problems. Complex, computationally intensive biological problems are now being addressed and promise to significantly advance our understanding of biology and medicine. No biological discipline will be unaffected by these technological breakthroughs.”
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