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{bio,medical} informatics


Saturday, October 21, 2000

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find related articles. powered by google. Science The Babel of Bioinformatics
[summary - can be viewed for free once registered]
"As more and more genomes are sequenced, it is becoming clear that deciphering the clues latent in these sequences is anything but trivial. In this Techview, Attwood analyzes the current state of the art in sequence-structure-function bioinformatics. She highlights the need for precise terminology, and argues that a holistic view of complex biological systems will be an essential next step for bioinformatics.”
redux [08.12.00]
find related articles. powered by google. GenomeBiology Whither genomics?
"The flood of data from genome-wide analysis is transforming biology. We need to develop new, interdisciplinary approaches to convert these data into information about the components and structures of individual biological pathways and to use the resulting information to yield knowledge about general principles that explain the functions and evolution of life."

"Genomics increases the chance that biology will experience a split like the one in physics, between those who collect and those who analyze data. This will challenge the majority of biologists who believe that modeling, simulation, and theory have little to contribute to biology. This prejudice rests on insecurity engendered by most biologists' weakness in mathematics (including my own) and previous efforts to model systems using more variables than there were data points. If we keep clinging to this prejudice, we will drown in a sea of data."

redux [07.25.00]
find related articles. powered by google. The Scientist The Language of Bioinformatics
[requires 'free' registration]
"Once the world had a single language and not too many words, but then clarity deteriorated into clamor. Today in the small but prolific world of bioinformatics, another Tower of Babel is rising up, with the miscommunication due as much to the rapid expansion of information as to basic changes in how it is processed. "Horrible problems" crop up as more information is computed on instead of read by a human researcher, according to Ewan Birney, a group leader in the Ensembl genome annotation project at the European Bioinformatics Institute (EBI) in Cambridge, England.

In the early days of bioinformatics, human-readable data exchange formats such as ASN.1, the format adopted for GenBank by the National Center for Biotechnology Information (NCBI) 10 years ago, were the norm. Easily editable with a text utility, ASN.1's syntactic looseness makes it congenial to the human user, but not to the machine, which likes its inputs defined with dictatorial rigidity."


[ rhetoric ]

Bioinformatics will be at the core of biology in the 21st century. In fields ranging from structural biology to genomics to biomedical imaging, ready access to data and analytical tools are fundamentally changing the way investigators in the life sciences conduct research and approach problems. Complex, computationally intensive biological problems are now being addressed and promise to significantly advance our understanding of biology and medicine. No biological discipline will be unaffected by these technological breakthroughs.

BIOINFORMATICS IN THE 21st CENTURY

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