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Saturday, July 08, 2000

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SFGate UC Santa Cruz Puts Human Genome Online Programming wizard does job in 4 weeks
"The human genome has been called the Book of Life, but it's one tome few have ever seen.

That started to change yesterday, after the University of California at Santa Cruz unveiled a Web site -- -- where people can download the only completely assembled version of the human genetic code for free."

""I downloaded it at home over my DSL line in about an hour and a half,'' said David Haussler, the computer science professor who helped develop the Web site."
UCSC Human Genome Project Working Draft Sequence
"This page contains links to a preliminary assembly of the current draft of the human genome. The human genome is approximately 3.1 billion bases. Roughly 85% of the genome has been sequenced by the International Human Genome Project. The June 15 draft genome is composed of hundreds of thousands of fragments of various sizes. The order and orientation of the fragments is often not known from the sequencing process itself. In some cases the same part of the genome will be duplicated in several fragments."

This assembly of the accessions is an attempt to merge together overlapping fragments, and to order and orient non-overlapping fragments based on mRNA, EST, and BAC end pair alignment information. The ordering and orientation is far from perfect, yet it still should be useful to many researchers. Much of the redundancy found in the human genomic clones submitted to GenBank and EMBL is removed in this working draft. The average contig size is substantially larger in it than in the records for individual clones.”
[via slashdot]

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Bioinformatics will be at the core of biology in the 21st century. In fields ranging from structural biology to genomics to biomedical imaging, ready access to data and analytical tools are fundamentally changing the way investigators in the life sciences conduct research and approach problems. Complex, computationally intensive biological problems are now being addressed and promise to significantly advance our understanding of biology and medicine. No biological discipline will be unaffected by these technological breakthroughs.


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