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{bio,medical} informatics

Tuesday, June 13, 2000

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The Scientist Pursuing Proteomes
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"Australian postdoctoral fellow Marc Wilkins coined the term "proteome" in the mid-'90s, referring to the total set of proteins expressed in a given cell at a given time. The term took hold, and a new scientific discipline was born. In proteomic studies, all the proteins from a given cell, organelle, or tissue are analyzed simultaneously with respect to properties such as expression levels, posttranslational modifications, and interactions with other molecules. Proteomics is a young discipline but is rapidly growing due to the development, integration, and automation of requisite large-scale analytical tools and the emergence of sophisticated bioinformatic techniques. The push is on to obtain global, integrated views of disease states and cellular processes at the proteome level."

[ rhetoric ]

Bioinformatics will be at the core of biology in the 21st century. In fields ranging from structural biology to genomics to biomedical imaging, ready access to data and analytical tools are fundamentally changing the way investigators in the life sciences conduct research and approach problems. Complex, computationally intensive biological problems are now being addressed and promise to significantly advance our understanding of biology and medicine. No biological discipline will be unaffected by these technological breakthroughs.


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